Choline alfoscerate

By Li Sang(李桑） | Updated: 2018-05-12 13:50:19

General Information

Product name: Choline alfoscerate, Choline glycerophosphate

Other name: Alpha GPC, L-ALPHA-Glycerophosphoryl choline; Choline Glycerophosphate; (2S)-2, 3-dihydroxypropyl-2-(trimethylammonio)ethyl phosphate; (2R)-2,3-dihydroxypropyl 2-(trimethylammonil)ethyl phosphate.

CAS No.: 28319-77-9

Formula: C8H20NO6P

Mol.Mass: 257.22

Mol.structure: 

 

Appearance: Clear and viscous liquid

Assay: 98.5%-102.0%

Package: 25kg/20kg/5kg of choline alfoscerate are filled into threefold polythene bags for medicinal purpose, each bag is sealed with nylon cable ties. Then the sealed bags are placed into blue plastic drum. Cover the lid and seal the drum.

Studies have investigated its efficacy for cognitiove disorders including stroke and Alzheimer’s Disease. An Italian muliticentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400mg three times per day for the five ensuring months. The trial confirmes the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance.

Foreign Names

Cholini alfosceras(Latin)

Choline alfoscerat(German)

Alfoscerate de choine(French)

Alfoscerato de colina(Spanish)

Generic Names

Choline Glycerophosphate(IS)

Glicerofosfato de colina(IS)

Glycerophosphate de choline(IS0

GPC L-a(IS)

L-alpha-Glycerylphosphorylcholine(IS)

a-gpc(IS)

Choline alfoscerate(Also known as Alpha-GPC) is L-a-glycerylcholine(GPC), a key brain cell menbrane phospholipid and cholinergic precursor. It is a source of choline for the synthesis of the neurotransmitter acetylcholine, with a greater ability to penetrate the blood-brain barrier than conventional choline sources.

More importantly, Choline alfoscerate has been ecperimentally demonstrated to reduce or reverse age-related structural changes in the frontal cortex and hippocampue and induces functional deficiencies of the cholinergic system. Research supports choline alfoscerate’s ability to support healthy brain function and the release of somatotrophin(hGH).

While complex mental process like memory and attention cannot be reduced to a single, simple chemical pathway, it is undeniable that the function of the cholinergic system of the brain-those aspects of brain function involving a neurotransmitter(brain messenger-molecule) called acetycholine(ACh)-is central to our mental function, and especially our ability to focus and to remember facts and verbal information. Acetycholine is made in the nervous system from a B-vitamin-like raw material called choline. When a person is young, the more choline he or she takes in from diet and supplements, the more ACh gets made, the better his or her menory becomes. As we age, that strategy becomes less and less effective, because the structure and function of the cholinergic system itself suffers a slow, insidious decline.

The aging brain’s  cholinergic function is impaired at several points, all of which affect mental performance:

The ability of the brain t take in necessary raw materials.

The loss of balance in key cholinergic enzyme.

The loss of choinergic neurons.

Choline alfoscerate(al-FOSS-er-ate), or alpha-glycerylphosphorucholine(GPC), is a phospholipid - a complex fatty substance containing phosphorous, like phosphatidylserine and phosphatidylcholine - and  is an important building block in the construction of nerve cell membranes.

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